Is it safe to use a Lubricant when trying for pregnancy? Dr. Anjali Kumar Maitri Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Premom Fertility Friendly Lubricant: Designed for Women Trying to Conceive Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex The most pregnancy friendly lubricants are the water based kinds. These lubes are water soluble, which means they dissolve in water. They're safer for you and your baby, typically because they contain fewer chemicals than