How Many Cigarettes Are in a Vape? Clear Answers Blakk Smoke Doctor says smoking one vape is equivalent of disturbing amount of cigarettes Vaping isn't just a "safer" alternative; it comes with hidden costs to your health. A single disposable vape can have up to 5,000 puffsthe equivalent of 25 packs of cigarettes. Beyond the Which e cigarette is most like my favourite cigarette? : The Electric Tobacconist Ltd. Which e cigarette is most like my favourite cigarette? : The Electric Tobacconist Ltd. How Many Puffs of Vape are Equal to a Cigarette? EDGE Vaping